Description

Penitrem A is a potent tremorgenic mycotoxin produced by various species of Penicillium and Aspergillus fungi. This compound is of significant interest in toxicological and pharmacological research due to its specific neurotoxic effects, primarily acting as a blocker of high-conductance calcium-activated potassium (BK) channels. It serves as a critical reference standard and research tool for scientists in the fields of neurobiology, mycotoxicology, and food safety, enabling the study of neurological disorders, channelopathies, and the detection of fungal contamination.

Application

• Neurobiological Research: Used as a selective pharmacological tool to study the function and modulation of large-conductance calcium-activated potassium (BK) channels in neuronal and smooth muscle tissues.
• Toxicology Studies: Employed as a reference standard in the investigation of tremorgenic mycotoxin poisoning, its mechanisms of action, and potential treatments.
• Analytical Reference Standard: Serves as a high-purity calibrant in analytical methods such as HPLC-MS/MS and LC-MS for the accurate quantification of Penitrem A in complex matrices like food, feed, and environmental samples.
• Food & Feed Safety: Critical for developing and validating detection assays to monitor and control Penicillium contamination in agricultural products, ensuring consumer and livestock safety.
• Pharmacological Probes: Utilized in preclinical research to model neurological symptoms and explore the pathophysiology of tremors and other motor dysfunctions.

Basic Information

Product Name	Penitrem A
CAS No.	12627-35-9
Molecular Formula	C37H44ClNO6
Molecular Weight	634.20 g/mol
Synonyms	Penitrem A; Tremortin; NSC 169785; Penitrem; 2,3,4,4a,5,6,7,8,11,11a-Decahydro-3,11a-dihydroxy-6,10b-dimethyl-3-(2-methyl-1-propen-1-yl)-2-oxospiro[4,4a-epoxy-11H-benzo[7,8]fluoreno[9,8a-b]oxirene-5,3'-piperidine]-9-carboxylic acid 4-chlorobenzyl ester
EINECS	Contact for details

Quality Control

Our Penitrem A is produced and handled under strict quality protocols to ensure the highest standards of purity and consistency for research applications. Each batch is thoroughly characterized using advanced analytical techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and ensure long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.