Description

3-Amino-2,2,5,7-tetramethyl-2,3-dihydro-1H-inden-4-ol is a specialized indane derivative featuring both amino and phenolic hydroxyl functional groups, making it a versatile chiral building block and intermediate. This compound is valued for its unique sterically hindered structure, which is critical for synthesizing complex molecules with specific stereochemical and electronic properties. It is primarily sought by research and development teams in the pharmaceutical and advanced materials sectors for applications in asymmetric synthesis, ligand development, and the creation of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Catalyst Ligand: Used in the development of proprietary ligands for transition metal catalysis, enabling enantioselective transformations.
• Advanced Material Synthesis: Acts as a monomer or functional additive in the production of specialty polymers and organic electronic materials.
• Agrochemical Research: Employed as a building block for creating new active ingredients with enhanced efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Fine Chemical Production: Integral to multi-step synthetic routes for high-value, low-volume specialty chemicals.

Basic Information

Product Name	3-Amino-2,2,5,7-tetramethyl-2,3-dihydro-1H-inden-4-ol
CAS No.	93747-39-8
Molecular Formula	C₁₃H₁₉NO
Molecular Weight	205.30 g/mol
Synonyms	4-Hydroxy-2,2,5,7-tetramethyl-2,3-dihydro-1H-inden-3-amine; 3-Amino-4-hydroxy-2,2,5,7-tetramethylindane; 2,2,5,7-Tetramethyl-3-amino-2,3-dihydro-1H-inden-4-ol; Tetramethyl aminoindanol; 3-Amino-4-indanol derivative; Amino-tetramethylindanol; Chiral indanol amine
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-2,2,5,7-tetramethyl-2,3-dihydro-1H-inden-4-ol is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all shipments. Our quality protocols are designed to support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.