Description

Caffeine Citrate is a pharmaceutical-grade salt formed from caffeine and citric acid, offering enhanced solubility and stability for precise formulation. This compound is critical for ensuring consistent bioavailability and therapeutic efficacy in medical applications. It is primarily required by manufacturers in the pharmaceutical and nutraceutical industries for developing respiratory stimulants and other specialized drug products.

Application

• Pharmaceutical Formulations: Key active ingredient in injectable solutions and oral suspensions for the treatment of apnea of prematurity in neonates.
• Respiratory Stimulants: Used in central nervous system stimulants to manage bronchopulmonary dysplasia and post-operative respiratory depression.
• Nutraceutical & Dietary Supplements: Incorporated into advanced energy and cognitive support supplements requiring highly soluble caffeine sources.
• Analytical Reference Standards: Serves as a high-purity certified reference material (CRM) for quality control and research laboratories.
• Veterinary Medicine: Applied in formulations for respiratory and cardiac stimulation in veterinary care.
• Research & Development: Utilized in preclinical and clinical studies investigating the pharmacokinetics of caffeine salts.

Basic Information

Product Name	Caffeine Citrate
CAS No.	93390-81-9
Molecular Formula	C14H18N4O9
Molecular Weight	386.31 g/mol
Synonyms	Caffeine Citrate Salt; Citrated Caffeine; 1,3,7-Trimethylxanthine Citrate; Theine Citrate; Caffeine and Citric Acid Compound; Caffeine Citrate USP; Cafcit (Brand Name Equivalent); Caffeine Hydrogen Citrate
EINECS	Contact for details

Quality Control

Our Caffeine Citrate is manufactured and tested to meet stringent pharmaceutical standards, including USP monograph requirements. Every batch undergoes comprehensive analytical testing for identity, potency, and purity. A Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and microbiological attributes is provided to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 0.5% Any individual impurity ≤ 0.1%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Microbiological Control	Total Aerobic Microbial Count ≤ 1000 cfu/g Total Combined Yeasts/Molds ≤ 100 cfu/g Absence of E. coli, Salmonella

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.