Description

Picrotoxin CAS NO 124-87-8 is a potent, non-competitive antagonist of GABA-A receptors, acting as a central nervous system stimulant. This compound is of significant value in neuroscience research for its ability to induce convulsions and study inhibitory neurotransmission pathways. It is primarily required by pharmaceutical R&D laboratories, academic research institutions, and chemical manufacturers focused on developing neuropharmacological tools and reference standards.

Application

• Neuroscience Research: Used as a standard pharmacological tool to block GABAergic inhibition and study seizure mechanisms, neuronal excitability, and synaptic plasticity.
• Reference Standard: Serves as a high-purity analytical standard in quality control laboratories for the identification and quantification of picrotoxin in various matrices.
• Pharmacological Studies: Employed in vitro and in vivo to investigate the function of GABA-A receptor subtypes and to screen potential anticonvulsant or sedative-hypnotic drugs.
• Biochemical Reagent: Utilized in biochemical assays to probe the role of GABA-mediated inhibition in cellular and tissue preparations.
• Toxicology Research: Applied in studies modeling convulsive states and investigating the neurotoxicological profiles of related compounds.

Basic Information

Product Name	Picrotoxin
CAS No.	124-87-8
Molecular Formula	C30H34O13
Molecular Weight	602.59 g/mol
Synonyms	Cocculin; Picrotox; Picrotoxinum; Cocculus toxin; Menispermine; (1R,2S,3S,5R,6S,8S,9S,11R,12R)-8-(Hydroxymethyl)-2,6:9,13-diepoxy-11-(β-D-glucopyranosyloxy)-14-oxatetracyclo[7.5.0.03,7.011,15]tetradecane-4,10-dione
EINECS	204-716-3

Quality Control

Our Picrotoxin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity determination by HPLC, to ensure it meets exacting standards for research use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be kept in secondary packaging or a dark storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.