Description

2'-Fluoro-6'-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a reactive acetyl group with a phenolic hydroxyl and a fluorine substituent in ortho positions, enabling precise chemical modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly as a precursor for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used as a building block for developing new herbicides and pesticides with enhanced biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel bidentate ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of advanced polymers and liquid crystals where fluorine incorporation modifies physical properties.
• Fluorine Chemistry Studies: A valuable substrate for investigating ortho-substitution effects and fluorine-directed regioselectivity in organic reactions.
• Custom Synthesis: Provides a versatile starting point for contract research organizations (CROs) and fine chemical manufacturers engaged in custom synthesis projects.

Basic Information

Product Name	2'-Fluoro-6'-Hydroxyacetophenone
CAS No.	93339-98-1
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	1-(2-Fluoro-6-hydroxyphenyl)ethanone; 2'-Fluoro-6'-hydroxyacetophenone; 2-Fluoro-6-hydroxyacetophenone; 2-Acetyl-3-fluorophenol; 1-Acetyl-2-fluoro-6-hydroxybenzene; 2-Fluoro-6-acetylphenol; Ethanone, 1-(2-fluoro-6-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-6'-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.