Description

4-Methyl-2,3,5,6-Tetrafluorobenzyl Bromide is a versatile and highly reactive organofluorine building block, essential for introducing the tetrafluorobenzyl moiety into complex molecular architectures. Its primary value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced properties such as metabolic stability and lipophilicity. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronics: Employed in the synthesis of fluorinated semiconductors and charge-transport materials for OLEDs and organic photovoltaics.
• Fluorinated Polymer Modifier: Acts as a monomer or cross-linking agent to create polymers with improved chemical resistance, thermal stability, and low surface energy.
• Positron Emission Tomography (PET) Tracer Precursor: Utilized in radiochemistry for labeling compounds with fluorine-18 for medical imaging.
• Chemical Research & Development: A fundamental reagent for exploring new fluorination methodologies and creating novel fluorinated scaffolds in academic and industrial labs.

Basic Information

Product Name	4-Methyl-2,3,5,6-Tetrafluorobenzyl Bromide
CAS No.	92814-00-1
Molecular Formula	C8H5BrF4
Molecular Weight	257.03 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-methylbenzyl Bromide; (2,3,5,6-Tetrafluoro-4-methylphenyl)methyl Bromide; α-Bromo-2,3,5,6-tetrafluoro-4-methyltoluene; 4-Methyltetrafluorobenzyl Bromide; 4-Methylperfluorobenzyl Bromide; 1-(Bromomethyl)-2,3,5,6-tetrafluoro-4-methylbenzene; TFB-Br (common abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 4-Methyl-2,3,5,6-Tetrafluorobenzyl Bromide is manufactured and tested under strict quality management systems. We ensure compliance with relevant industry standards, and our quality control includes rigorous analytical testing to guarantee identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.