Description

cis-3-Amino-2,2-Dimethylcyclobutanecarboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant chiral building block. This compound is valued for its rigid, constrained cyclobutane structure, which is crucial for modulating the conformation and metabolic stability of bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including peptide mimetics and small molecule drugs targeting neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing receptor selectivity, proteolytic stability, and oral bioavailability.
• Chemical Biology & Proteomics: Serves as a specialized amino acid analog for probing enzyme active sites or designing activity-based probes.
• Agrochemical Research: Employed in the discovery of new herbicides and pesticides, leveraging its unique steric and electronic properties.
• Catalyst & Ligand Development: Acts as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Process Chemistry: Used in methodological studies and scale-up process development for complex organic molecules.

Basic Information

Product Name	cis-3-Amino-2,2-Dimethylcyclobutanecarboxylic Acid Hydrochloride
CAS No.	92812-22-1
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	(1R,3S)-3-Amino-2,2-dimethylcyclobutanecarboxylic acid hydrochloride; (1S,3R)-3-Amino-2,2-dimethylcyclobutanecarboxylic acid hydrochloride; 3-Amino-2,2-dimethylcyclobutanecarboxylic acid HCl; cis-3-AADCB HCl; 2,2-Dimethyl-3-aminocyclobutanecarboxylic acid hydrochloride; 3-Amino-2,2-dimethyl-1-cyclobutanecarboxylic acid monohydrochloride; (cis)-3-Amino-2,2-dimethylcyclobutanecarboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our cis-3-Amino-2,2-Dimethylcyclobutanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.