Description

1-(2,4-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both chlorine and trifluoromethyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and enhance the metabolic stability of target compounds.

Application

This specialized chemical intermediate serves critical roles in several high-value industrial sectors:

• Pharmaceutical Intermediates: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl or dichlorophenyl motifs to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where its halogenated structure contributes to product efficacy and environmental profile.
• Material Science Research: Serves as a precursor for novel fluorinated polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences market.
• Academic & Industrial R&D: Employed in methodological development and discovery chemistry for creating new carbon-fluorine and carbon-chlorine bond-forming reactions.

Basic Information

Product Name	1-(2,4-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone
CAS No.	92736-81-7
Molecular Formula	C8H3Cl2F3O
Molecular Weight	243.01 g/mol
Synonyms	2,4-Dichloro-α,α,α-trifluoroacetophenone; 2',4'-Dichloro-2,2,2-trifluoroacetophenone; 1-(2,4-Dichlorophenyl)-2,2,2-trifluoroethanone; 2,4-Dichloro-ω,ω,ω-trifluoroacetophenone; α,α,α-Trifluoro-2,4-dichloroacetophenone; (2,4-Dichlorophenyl)trifluoromethyl ketone; TFAP-DCl
EINECS	Contact for details

Quality Control

Our 1-(2,4-Dichloro-Phenyl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply for critical development and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.