Description

(1As,8As)-7α-Chlorooctahydro-3β-Hydroxy-3,4Aα,8,8-Tetramethyl-3H-Naphth[1,8A-B]Oxirene-4α-Carboxylic Acid Methyl Ester is a high-purity, complex organic intermediate featuring a unique oxirene (epoxide) ring fused to a decalin core. This compound matters as a critical chiral building block for the synthesis of advanced pharmaceutical compounds and fine chemicals, offering a rigid, functionalized scaffold for medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in areas requiring sophisticated stereochemical control.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, especially those targeting neurological or metabolic pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct molecules with high enantiomeric purity.
• Fine Chemical Production: Acts as a specialized intermediate for manufacturing high-value agrochemicals, flavors, or fragrances requiring specific stereochemistry.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and the study of epoxide reactivity.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(1As,8As)-7α-Chlorooctahydro-3β-Hydroxy-3,4Aα,8,8-Tetramethyl-3H-Naphth[1,8A-B]Oxirene-4α-Carboxylic Acid Methyl Ester
CAS No.	92675-15-5
Molecular Formula	C₁₈H₂₇ClO₄
Molecular Weight	342.86 g/mol
Synonyms	7α-Chloro-3β-hydroxy-3,4aα,8,8-tetramethyl-1,2,3,4,4a,5,6,8a-octahydronaphth[1,8a-b]oxirene-4α-carboxylic acid methyl ester; Methyl (1aS,4aR,8aS)-7-chloro-3-hydroxy-3,4a,8,8-tetramethyl-1,1a,4,4a,5,6,8,8a-octahydronaphtho[1,8a-b]oxirene-4-carboxylate; 7α-Chloro-3β-hydroxy-3,4aα,8,8-tetramethylperhydronaphth[1,8a-b]oxirene-4α-carboxylic acid methyl ester; NSC 339586; A derivative of sclareolide oxide.
EINECS	Contact for details

Quality Control

Our (1As,8As)-7α-Chlorooctahydro-3β-Hydroxy-3,4Aα,8,8-Tetramethyl-3H-Naphth[1,8A-B]Oxirene-4α-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.