Description

Saframycin F CAS NO 92569-03-4 is a potent member of the saframycin family of antitumor antibiotics, characterized by its unique pyrrolo[1,4]benzodiazepine (PBD) dimer structure. This compound is of significant interest in pharmaceutical research and development due to its potent biological activity, primarily its ability to bind DNA and inhibit topoisomerase I. It is a critical building block and reference standard for researchers and manufacturers in the fields of oncology drug discovery, molecular biology, and the synthesis of novel bioactive compounds.

Application

• Oncology Research & Drug Discovery: Serves as a key reference standard and pharmacophore model for developing novel anticancer agents targeting DNA.
• Biochemical Research: Used as a potent tool compound in studies of DNA-interactive agents, topoisomerase I inhibition, and apoptosis mechanisms.
• Pharmaceutical Intermediate: Acts as a sophisticated intermediate in the synthetic pathways for more complex antitumor antibiotics and antibody-drug conjugates (ADCs).
• Academic & Institutional Research: Employed in university and institutional labs for chemical biology studies and structure-activity relationship (SAR) investigations.
• Standards & Calibration: Utilized as a high-purity certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Saframycin F
CAS No.	92569-03-4
Molecular Formula	C28H30N4O7
Molecular Weight	534.56 g/mol
Synonyms	Saframycin F; NSC 339638; Antibiotic AT 2433-A1; (1S,11S,12S,13S,14S,32S,33S,34S,35S)-12,34-Bis(hydroxymethyl)-11,14,33,35-tetramethyl-3,22,26-trioxo-2,7,21,25-tetraazaheptacyclo[14.12.2.13,6.18,13.119,24.020,34.027,32]pentatriaconta-4,6(35),8,10,12,16,18,20(34),23,25(33)-decaene-13,32-diol
EINECS	Contact for details

Quality Control

Our Saframycin F is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep the container in a dry, well-ventilated area dedicated for the storage of potent bioactive compounds.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC-MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.