Description

β-Lapachone is a naturally occurring ortho-naphthoquinone compound derived from the bark of the Lapacho tree, recognized for its potent and selective biological activity. Its primary commercial value lies in its role as a promising pharmacological agent, particularly in oncology research and drug development. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors, where it is used as a critical reference standard and active pharmaceutical ingredient (API) intermediate.

Application

• Oncology Research & Drug Discovery: A key investigational compound for studying NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated apoptosis in cancer cells.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of novel therapeutic agents targeting various diseases.
• Biochemical Research: Used as a specific probe to induce programmed necrosis and study reactive oxygen species (ROS) generation mechanisms in cellular models.
• Reference Standard: Employed in analytical laboratories for method development, validation, and quality control of related pharmaceutical products.
• Antiparasitic Studies: Investigated for its activity against parasites such as *Trypanosoma cruzi* and *Leishmania* species.
• Anti-inflammatory Research: Studied for its potential to modulate inflammatory pathways and immune responses.

Basic Information

Product Name	β-Lapachone
CAS No.	4707-32-8
Molecular Formula	C15H14O3
Molecular Weight	242.27 g/mol
Synonyms	β-Lapachone; 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione; Lapachol derivative; NSC-26326; (-)-β-Lapachone; 2,2-Dimethyl-3,4-dihydro-2H-benzo[h]chromene-5,6-dione; ARQ 501
EINECS	225-189-5

Quality Control

Our β-Lapachone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets stringent specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to prevent oxidation and degradation. The container must be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.