Description

4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Bromide is a specialized benzyl bromide derivative featuring a photoreactive trifluoromethyl-diazirine functional group, making it a critical intermediate for advanced chemical synthesis. Its primary value lies in enabling photoaffinity labeling (PAL), a powerful technique for studying biomolecular interactions and drug discovery. This high-purity reagent is essential for researchers and manufacturers in pharmaceutical R&D, agrochemical development, and materials science who require reliable, high-quality building blocks for creating probes and covalent inhibitors.

Application

• Photoaffinity Labeling (PAL) Probes: Serves as a key photoreactive precursor for synthesizing molecular probes to study protein-ligand interactions, enzyme active sites, and biological target identification.
• Pharmaceutical Research: Used in the development of covalent drug candidates and activity-based protein profiling (ABPP) agents for target validation and lead optimization.
• Chemical Biology Tools: Enables the synthesis of trifluoromethylphenyl diazirine (TPD)-based crosslinkers for mapping protein-protein interactions and structural biology studies.
• Agrochemical Discovery: Employed as an intermediate in creating novel bioactive compounds with potential herbicidal or insecticidal properties.
• Materials Science: Functions as a surface modification agent or a monomer precursor for introducing photoreactive and fluorinated groups into polymers and advanced materials.
• Proteomics & Biomarker Research: Integral to creating reagents for identifying and characterizing low-abundance proteins and transient binding events.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Bromide
CAS No.	92367-11-8
Molecular Formula	C9H6BrF3N2
Molecular Weight	279.06 g/mol
Synonyms	3-(4-(Bromomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine; 4-(3-(Trifluoromethyl)diazirin-3-yl)benzyl bromide; 3-(4-Bromomethylphenyl)-3-(trifluoromethyl)diazirine; TPD-Benzyl-Br; Photoaffinity Labeling Benzyl Bromide; Trifluoromethylphenyl Diazirine Benzyl Bromide; Benzyl Bromide TPD Derivative; (4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenyl)methanol bromide
EINECS	Contact for details

Quality Control

Our 4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Benzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and chemical biology, ensuring reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong acids and organic solvents. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.