Description

Ethyl 2-Methyl-3-Hydroxy-4,4,4-Trifluorobutyrate is a versatile fluorinated organic ester that serves as a critical chiral building block in advanced chemical synthesis. Its value lies in the trifluoromethyl group, which imparts unique properties like enhanced metabolic stability and lipophilicity to target molecules. This high-purity intermediate is essential for research and production in the pharmaceutical and agrochemical industries, where precise molecular architecture is paramount.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the CF3 group enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Used in the development of fluorinated components for advanced display technologies due to its influence on dielectric anisotropy and viscosity.
• Organic Synthesis Reagent: Employed in asymmetric synthesis and medicinal chemistry research for introducing the 2-methyl-3-hydroxy-4,4,4-trifluorobutyl moiety.
• Flavor & Fragrance Industry: Potential precursor for specialty fluorinated aroma chemicals, though specific applications require regulatory evaluation.

Basic Information

Product Name	Ethyl 2-Methyl-3-Hydroxy-4,4,4-Trifluorobutyrate
CAS No.	91600-33-8
Molecular Formula	C7H11F3O3
Molecular Weight	200.16 g/mol
Synonyms	Ethyl 2-Methyl-3-hydroxy-4,4,4-trifluorobutanoate; 4,4,4-Trifluoro-3-hydroxy-2-methylbutyric Acid Ethyl Ester; 3-Hydroxy-2-methyl-4,4,4-trifluorobutanoic Acid Ethyl Ester; (R/S)-Ethyl 2-Methyl-3-hydroxy-4,4,4-trifluorobutyrate; 91600-33-8; Ethyl 3-Hydroxy-2-methyl-4,4,4-trifluorobutyrate; TFMB Ethyl Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Methyl-3-Hydroxy-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for pharmaceutical and fine chemical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect product stability and performance.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as required)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.