Description

2-Difluoromethyl-Benzoxazole is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is prized for its role in introducing the difluoromethyl group, a key bioisostere that can significantly alter the metabolic stability, lipophilicity, and binding affinity of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group enhances biological activity and environmental profile.
• Material Science Research: Serves as a precursor for synthesizing specialized fluorinated polymers, liquid crystals, and organic electronic materials with unique properties.
• Chemical Biology & Proteomics: Employed as a building block for designing activity-based probes and molecular tags to study enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Difluoromethyl-Benzoxazole
CAS No.	91437-09-1
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	2-(Difluoromethyl)-1,3-benzoxazole; Benzoxazole, 2-(difluoromethyl)-; 2-(Difluoromethyl)benzoxazole; 91437-09-1; DFBO
EINECS	Contact for details

Quality Control

Our 2-Difluoromethyl-Benzoxazole is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.