Description

Benzene, 2-(Bromomethyl)-1-Fluoro-4-Methoxy- is a high-purity fluorinated and brominated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its unique bifunctional reactivity, offering distinct handles for nucleophilic substitution via the bromomethyl group and for further functionalization via the electron-deficient fluorinated aromatic ring. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated benzene cores with pendant alkylating functionality.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Cross-Coupling Reactions: The bromomethyl group is amenable to various metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for carbon-carbon bond formation.
• Ligand and Catalyst Development: Useful for synthesizing novel fluorinated ligands for catalysis and molecular recognition applications.
• Polymer Modification: Employed to introduce fluorinated aromatic units into polymer backbones to alter thermal, chemical, and surface properties.

Basic Information

Product Name	Benzene, 2-(Bromomethyl)-1-Fluoro-4-Methoxy-
CAS No.	91319-42-5
Molecular Formula	C8H8BrFO
Molecular Weight	219.05 g/mol
Synonyms	1-Fluoro-2-(bromomethyl)-4-methoxybenzene; 2-Bromomethyl-1-fluoro-4-methoxybenzene; 4-Methoxy-2-(bromomethyl)fluorobenzene; (2-Bromomethyl-4-methoxyphenyl)fluoride; α-Bromo-3-fluoro-6-methoxytoluene; 3-Fluoro-6-methoxybenzyl bromide
EINECS	Contact for details

Quality Control

Our Benzene, 2-(Bromomethyl)-1-Fluoro-4-Methoxy- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available for every shipment, providing full traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.