Description

1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, trans- (9Ci) CAS NO 91237-23-9 is a specialized, high-purity aldehyde derivative featuring a protected dioxolane ring system. This compound serves as a versatile and valuable chiral building block in advanced organic synthesis, enabling the construction of complex molecular architectures. It is particularly critical for research and development chemists in the pharmaceutical and agrochemical industries seeking to introduce specific stereochemistry and functional groups into target molecules. Its defined trans-configuration and reactive aldehyde moiety make it an essential intermediate for producing active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in antiviral, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for biological activity.
• Fine Chemical Production: Employed as a building block for creating complex flavors, fragrances, and specialty performance chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological development in asymmetric synthesis and catalysis studies within chemistry laboratories.
• Material Science Precursor: Potential use in synthesizing specialized monomers for polymers with unique properties.

Basic Information

Product Name	1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, trans- (9Ci)
CAS No.	91237-23-9
Molecular Formula	C7H12O3
Molecular Weight	144.17 g/mol
Synonyms	(2R,4S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde; trans-2,2,5-Trimethyl-1,3-dioxolane-4-carbaldehyde; (4S)-2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde; 2,2,5-Trimethyl-1,3-dioxolane-4-carboxaldehyde, trans-; 4-Formyl-2,2,5-trimethyl-1,3-dioxolane; D-Glyceraldehyde Acetonide; (R)-Glyceraldehyde Acetonide (specific isomer)
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carboxaldehyde, 2,2,5-Trimethyl-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ISO guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and highly volatile. Keep away from heat, sparks, and open flame. Use appropriate grounding procedures during handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.