Description

2-Chloropyrimidine is a versatile halogenated heterocyclic building block essential for modern synthetic chemistry. Its primary value lies in its reactivity as an electrophile, enabling efficient nucleophilic aromatic substitution reactions to create complex molecular architectures. This compound is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, serving as a key precursor for active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of various drug candidates, including kinase inhibitors, antiviral agents, and other biologically active molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the pyrimidine core's bioactivity.
• Material Science: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An effective substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Nucleoside & Nucleotide Chemistry: Employed in the modification of nucleosides for medicinal chemistry and biochemical research.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.

Basic Information

Product Name	2-Chloropyrimidine
CAS No.	1722-12-9
Molecular Formula	C4H3ClN2
Molecular Weight	114.53 g/mol
Synonyms	2-Chloropyrimidine; Pyrimidine, 2-chloro-; 2-Pyrimidinyl chloride; NSC 9375; 2-Chloro-1,3-diazine; α-Chloropyrimidine; Chloropyrimidine
EINECS	217-012-5

Quality Control

Our 2-Chloropyrimidine is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality system supports the needs of cGMP manufacturing for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.