Description

2-Mercaptonicotinic Acid is a versatile sulfur-containing heterocyclic building block, primarily used as a key intermediate in the synthesis of complex organic molecules. Its value lies in its dual functionality, offering both a reactive thiol group and a carboxylic acid group for diverse chemical modifications. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of thiol-containing drug candidates, particularly for antiviral, antibacterial, and central nervous system (CNS) active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and fungicides where the mercapto group contributes to biological activity.
• Ligand for Metal Complexes: Serves as a chelating agent in coordination chemistry for creating catalysts or metal-organic frameworks (MOFs).
• Bioconjugation Chemistry: Utilized in the modification of peptides, proteins, and other biomolecules via thiol-specific coupling reactions.
• Material Science Research: Acts as a monomer or modifier in the synthesis of polymers and functional materials with specific electronic or adhesive properties.
• Chemical Research & Development: A valuable building block in organic synthesis for constructing complex nicotinic acid and pyridine derivatives.

Basic Information

Product Name	2-Mercaptonicotinic Acid
CAS No.	38521-46-9
Molecular Formula	C6H5NO2S
Molecular Weight	155.17 g/mol
Synonyms	2-Mercaptopyridine-3-carboxylic Acid; 3-Carboxy-2-mercaptopyridine; 2-Thionicotinic Acid; 2-Sulfanylpyridine-3-carboxylic Acid; 2-Pyridinethiol-3-carboxylic Acid; 3-Pyridinecarboxylic acid, 2-mercapto-; 2-Mercapto-3-pyridinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 2-Mercaptonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with key parameters including assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, consider using an inert atmosphere (e.g., nitrogen or argon) to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.