Description

2,2,2-Trifluoro-n-(Pyrrolidin-3-Ylmethyl)Ethanamine is a high-value fluorinated amine building block featuring a pyrrolidine scaffold. This compound is critical for medicinal chemistry and pharmaceutical research, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and CNS-targeting drugs.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and pesticides where the trifluoroethylamine moiety can improve lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts in asymmetric synthesis, leveraging the pyrrolidine nitrogen for coordination.
• Fluorinated Building Block: Essential for introducing the trifluoroethyl group into complex molecules to modulate physicochemical properties like solubility, bioavailability, and metabolic resistance.
• Peptidomimetics & Constrained Analogs: The pyrrolidine ring provides conformational restraint, making this compound valuable for designing peptide mimics and cyclic analogs in drug discovery.
• Material Science Precursor: Potential use in synthesizing fluorinated polymers or specialty chemicals with unique surface properties.

Basic Information

Product Name	2,2,2-Trifluoro-n-(Pyrrolidin-3-Ylmethyl)Ethanamine
CAS No.	91188-06-6
Molecular Formula	C7H13F3N2
Molecular Weight	182.19 g/mol
Synonyms	N-[(3-Pyrrolidinyl)methyl]-2,2,2-trifluoroethanamine; 2,2,2-Trifluoro-N-[(pyrrolidin-3-yl)methyl]ethanamine; 3-[(2,2,2-Trifluoroethylamino)methyl]pyrrolidine; 1-(3-Pyrrolidinylmethyl)-2,2,2-trifluoroethylamine; 2,2,2-Trifluoro-N-(pyrrolidin-3-ylmethyl)ethanamine; 91188-06-6; Pyrrolidine, 3-[[(2,2,2-trifluoroethyl)amino]methyl]-
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(Pyrrolidin-3-Ylmethyl)Ethanamine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization including NMR, HPLC, and GC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment. We support cGMP compliance for advanced intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and contains a fluoride/strong alkali moiety; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Isolate from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.