Description

4,4-Difluororetinol is a fluorinated derivative of retinol, a key compound in the vitamin A family. This specialized analog is valued for its enhanced stability and unique biological activity profile compared to its non-fluorinated counterpart, making it a critical intermediate for advanced research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel retinoid-based therapeutics, diagnostic agents, and high-value biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel fluorinated retinoid drugs targeting dermatological conditions, oncology, and metabolic disorders.
• Biochemical Research: Used as a stable, fluorinated probe to study retinol metabolism, receptor binding (RAR/RXR), and signaling pathways in cellular and molecular biology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical and nutritional analysis.
• Cosmeceutical R&D: Investigated for potential use in advanced skincare formulations due to its modified retinoid activity and stability.
• Organic Synthesis: A versatile fluorinated synthon for creating complex molecules in medicinal chemistry and material science projects.

Basic Information

Product Name	4,4-Difluororetinol
CAS No.	90660-21-2
Molecular Formula	C20H28F2O
Molecular Weight	322.44 g/mol
Synonyms	4,4-Difluoroall-trans-retinol; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4,4-difluoro-2,4,6,8-nonatetraen-1-ol; 4,4-Difluoro Vitamin A alcohol; 4,4-Difluoro-retinol; all-trans-4,4-Difluororetinol
EINECS	Contact for details

Quality Control

Our 4,4-Difluororetinol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.