Description

Proline, 4-Isopropyl- (6Ci,7Ci) CAS NO 90483-41-3 is a specialized proline derivative characterized by an isopropyl substitution at the 4-position of the pyrrolidine ring. This structural modification imparts unique steric and electronic properties, making it a valuable non-proteinogenic amino acid building block for advanced research and synthesis. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis sectors for developing novel peptides, chiral catalysts, and bioactive compounds.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapeutics.
• Peptide Chemistry: Used to incorporate structural constraints and enhance lipophilicity in custom peptide synthesis for drug discovery and biochemical studies.
• Asymmetric Catalysis: Employed as a precursor or ligand in the design of chiral catalysts for enantioselective synthesis.
• Agrochemical Research: Utilized in the synthesis of novel, biologically active compounds for crop protection and agricultural science.
• Bioconjugation & Labeling: Acts as a specialty linker or modified amino acid for bioconjugation strategies in probe and diagnostic reagent development.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic synthesis and medicinal chemistry within university and corporate laboratories.

Basic Information

Product Name	Proline, 4-Isopropyl- (6Ci,7Ci)
CAS No.	90483-41-3
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	4-Isopropylproline; 4-(1-Methylethyl)-L-proline (and other stereoisomers); 4-Isopropyl-2-pyrrolidinecarboxylic Acid; 4-(Propan-2-yl)proline; Non-proteinogenic amino acid derivative; Specialty proline analog
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for research applications. Our products undergo comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR, and MS for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee (specify isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.