Description

Polifeprosan is a high-purity, synthetic polymer specifically engineered for advanced pharmaceutical and biomedical applications. Its unique chemical structure provides exceptional control over drug release kinetics, making it a critical excipient in the development of long-acting, implantable, and targeted drug delivery systems. This material is essential for formulators and researchers in the pharmaceutical, biotechnology, and advanced medical device industries seeking to enhance therapeutic efficacy and patient compliance.

Application

• Controlled-Release Drug Delivery Systems: As a key biodegradable matrix for subcutaneous implants, microspheres, and injectable depots.
• Oncology Therapeutics: Used in localized, sustained-release formulations for chemotherapy, such as in Gliadel® wafers for brain cancer.
• Hormone Therapy: Enables long-term delivery of peptides, steroids, and other hormones from implantable devices.
• Ophthalmic Implants: Serves as a carrier in intravitreal implants for the treatment of chronic eye diseases.
• Biomedical Research: A vital tool in academic and industrial R&D for prototyping novel drug delivery platforms.
• Tissue Engineering: Potential use as a scaffold material due to its biocompatibility and tunable degradation profile.

Basic Information

Product Name	Polifeprosan
CAS No.	90409-78-2
Molecular Formula	(C22H14O4)n • (C2H2O2)m
Molecular Weight	Variable (Polymer)
Synonyms	Poly[bis(p-carboxyphenoxy)propane-sebacic acid]; PCPP-SA; Poly(1,3-bis(p-carboxyphenoxy)propane-co-sebacic acid); Gliadel Wafer copolymer; BCPP-SA; Polifeprosan 20; FAD: 1,3-Bis(p-carboxyphenoxy)propane and Sebacic Acid Copolymer
EINECS	Contact for details

Quality Control

Our Polifeprosan is manufactured under strict quality management systems to ensure batch-to-batch consistency and compliance with cGMP guidelines for pharmaceutical actives and excipients. Each lot is subjected to comprehensive analytical testing, including determination of copolymer ratio, molecular weight distribution, residual monomers, and impurity profiling. A detailed Certificate of Analysis (COA) documenting purity, identity, and performance characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation of polymer properties.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Copolymer Ratio (PCPP:SA)	20:80 (or as specified)
Inherent Viscosity	0.05 - 0.3 dL/g (specific conditions)
Assay (by Titration)	≥ 98.0 % (on anhydrous basis)
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Loss on Drying	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.