Description

17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin is a synthetic derivative of the natural product aplysiatoxin, a potent protein kinase C (PKC) activator. This compound is of significant interest in biochemical and pharmacological research due to its modified structure, which alters its biological activity and selectivity profile compared to the parent molecule. It serves as a critical tool compound for researchers in academic institutions, pharmaceutical R&D, and biotechnology companies studying signal transduction pathways, cancer biology, and inflammation.

Application

• Biochemical Research: Used as a selective probe to study the activation mechanisms and downstream effects of protein kinase C (PKC) isoforms in cellular models.
• Pharmacological Studies: Employed in structure-activity relationship (SAR) studies to develop novel therapeutic agents targeting PKC-related diseases.
• Oncology Research: Investigated for its effects on tumor promotion, cell proliferation, and apoptosis in cancer cell lines.
• Neuroscience: Applied in research on neurotransmitter release, neuronal plasticity, and the role of PKC in neurological disorders.
• Inflammation and Immunology: Used to modulate immune cell responses and study inflammatory signaling cascades.
• Chemical Biology: Serves as a molecular tool for developing new assays and screening platforms for drug discovery.

Basic Information

Product Name	17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin
CAS No.	90359-06-1
Molecular Formula	C32H46O9
Molecular Weight	574.71 g/mol
Synonyms	17-Debromoaplysiatoxin Derivative; 3-Deoxy-4-hydroxyaplysiatoxin; Debromo-dehydro-deoxy-hydroxyaplysiatoxin; Aplysiatoxin Analog; PKC Activator Derivative; 17-Debromo-2,3-didehydro-3-deoxy-4-hydroxyaplysiatoxin; (1R,2S,6S,7S,8S,11S,12S)-12-[(E)-But-1-en-1-yl]-11-hydroxy-2,6,8,12-tetramethyl-9-oxo-4,14-dioxatetracyclo[7.7.0.0²,⁷.0¹¹,¹⁵]hexadec-13-en-5-yl (2S,3S)-3-methoxy-2-methylpentanoate
EINECS	Contact for details

Quality Control

Our 17-Debromo-2,3-Didehydro-3-Deoxy-4-Hydroxyaplysiatoxin is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and structural confirmation via NMR and MS, to ensure high consistency and reliability for research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.