Description

2-Naphthyl 2-Diazo-3,3,3-Trifluoropropionate is a specialized diazo compound and trifluoromethylated building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring both a reactive diazo group and a trifluoromethyl moiety, makes it a valuable precursor for introducing fluorinated groups into complex molecules. This compound is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of fluorinated drug candidates, leveraging the trifluoromethyl group to modulate bioavailability and metabolic stability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of fluorine atoms can enhance activity and environmental profile.
• Advanced Material Synthesis: Employed in the creation of specialty polymers and liquid crystals that require precise fluorination for specific electronic or surface properties.
• Catalyst and Ligand Development: Acts as a precursor for generating metal carbene complexes used in catalytic cycles, such as cyclopropanation and C-H insertion reactions.
• Organic Synthesis Reagent: Utilized in [2+1] cycloadditions and other carbene transfer reactions to construct complex, fluorinated carbocyclic and heterocyclic structures.

Basic Information

Product Name	2-Naphthyl 2-Diazo-3,3,3-Trifluoropropionate
CAS No.	90038-07-6
Molecular Formula	C₁₄H₇F₃N₂O₂
Molecular Weight	292.21 g/mol
Synonyms	2-Diazo-3,3,3-trifluoro-1-(2-naphthyloxy)-1-propanone; 2-Naphthyl 2-diazo-3,3,3-trifluoropropanoate; 2-Naphthyl α-diazo-β,β,β-trifluoropropionate; 2-Naphthyl ester of 2-diazo-3,3,3-trifluoropropionic acid; β,β,β-Trifluoro-α-diazo-2-naphthoxyacetophenone; Diazo(trifluoromethyl)acetic Acid 2-Naphthyl Ester
EINECS	Contact for details

Quality Control

Our production of 2-Naphthyl 2-Diazo-3,3,3-Trifluoropropionate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.