Description

L-Proline, 1-2-3-Methyl-2-Oxo-4-Phenyl-3-(Phenylseleno)-1-Azetidinyl-1-Oxopropyl- is a specialized, high-value organoselenium compound derived from the amino acid L-proline. This advanced intermediate is critical for its role in the synthesis of complex molecules, particularly in the development of novel pharmaceuticals and bioactive agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the synthesis of β-lactam-based therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel β-lactam antibiotics and other bioactive molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its unique selenium-containing azetidinone scaffold.
• Process Chemistry: Serves as an advanced intermediate in the scalable synthesis of target drug candidates.
• Organoselenium Chemistry: A valuable reagent for studying selenium-mediated organic transformations and catalysis.
• Bioconjugation & Probe Development: Potential use in creating selenium-labeled probes for biochemical and diagnostic applications.

Basic Information

Product Name	L-Proline, 1-2-3-Methyl-2-Oxo-4-Phenyl-3-(Phenylseleno)-1-Azetidinyl-1-Oxopropyl-
CAS No.	90035-58-8
Molecular Formula	C23H24NO4Se
Molecular Weight	449.40 g/mol
Synonyms	(2S)-1-[(3S,4R)-3-Methyl-2-oxo-4-phenyl-3-(phenylselanyl)azetidin-1-yl]-3-phenyl-1-oxopropan-2-yl pyrrolidine-2-carboxylate; L-Proline, 1-[(3S,4R)-3-methyl-2-oxo-4-phenyl-3-(phenylseleno)-1-azetidinyl]-1-oxo-3-phenyl-2-propyl ester; Selenium-containing β-lactam-L-proline conjugate; 3-(Phenylseleno)-3-methyl-4-phenyl-2-azetidinone L-proline derivative; Organoseleno β-lactam prolinyl ester
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.