Description

4'-Trifluoromethyl-Biphenyl-4-Carbaldehyde is a high-purity aromatic aldehyde building block featuring a biphenyl core substituted with a trifluoromethyl group and a formyl group. This compound is valued for its role as a versatile synthetic intermediate, where the aldehyde functionality enables further chemical transformations and the trifluoromethyl group imparts desirable properties like enhanced metabolic stability and lipophilicity. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced molecules, including potential active ingredients and liquid crystal materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for display technologies (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport or host materials for OLED devices.
• Cross-Coupling Reactions: The aldehyde group makes it a suitable substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl systems.
• Chemical Research & Development: Used extensively in academic and industrial R&D labs for method development and exploring new chemical spaces in medicinal and materials chemistry.

Basic Information

Product Name	4'-Trifluoromethyl-Biphenyl-4-Carbaldehyde
CAS No.	90035-34-0
Molecular Formula	C14H9F3O
Molecular Weight	250.22 g/mol
Synonyms	4-Formyl-4'-(trifluoromethyl)biphenyl; [1,1'-Biphenyl]-4-carboxaldehyde, 4'-(trifluoromethyl)-; 4'-(Trifluoromethyl)biphenyl-4-carboxaldehyde; 4-(Trifluoromethyl)-[1,1'-biphenyl]-4'-carbaldehyde; 4'-Trifluoromethyl-4-biphenylcarboxaldehyde; p-Trifluoromethylbiphenyl-4-carbaldehyde; (4'-Trifluoromethyl-biphenyl-4-yl)-methanal
EINECS	Contact for details

Quality Control

Our 4'-Trifluoromethyl-Biphenyl-4-Carbaldehyde is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of our pharmaceutical and advanced materials clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.