Description

Physiogel is a high-purity, pharmaceutical-grade hyaluronic acid sodium salt, a critical biomaterial widely recognized for its exceptional biocompatibility and viscoelastic properties. This product is essential for formulators requiring a reliable, high-quality raw material that meets stringent pharmacopeial standards for sensitive medical and cosmetic applications. It is primarily utilized by manufacturers in the ophthalmic, dermatological, orthopedic, and advanced aesthetic medicine industries to develop innovative therapeutic and regenerative solutions.

Application

• Ophthalmic Surgery: As a viscoelastic agent in cataract extraction and intraocular lens implantation procedures to protect corneal endothelial cells and maintain anterior chamber depth.
• Injectable Dermal Fillers: A key component in cross-linked formulations for facial contouring, wrinkle correction, and volume restoration due to its excellent water-binding capacity and tissue integration.
• Wound Healing & Dermatology: Used in topical gels, sprays, and dressings to promote a moist healing environment, reduce inflammation, and support tissue regeneration for burns, ulcers, and dermatoses.
• Orthopedic Viscosupplementation: Formulated for intra-articular injections to supplement synovial fluid, providing lubrication and cushioning for osteoarthritic joints.
• Advanced Drug Delivery Systems: Serves as a biodegradable carrier or matrix for the controlled release of therapeutic agents in targeted therapies.
• Cosmetic Serums & Topicals: Incorporated into high-performance skincare products for its intense hydrating, smoothing, and film-forming properties.
• Tissue Engineering Scaffolds: Utilized as a foundational biomaterial in hydrogels and 3D matrices for cell culture and regenerative medicine applications.

Basic Information

Product Name	Physiogel
CAS No.	9049-67-6
Molecular Formula	(C14H20NNaO11)n
Molecular Weight	Variable polymer (typically 50,000 - 3,000,000 Da)
Synonyms	Hyaluronic Acid Sodium Salt; Sodium Hyaluronate; Hyaluronan Sodium; HA-Na; Hyaluronate Sodium; ARTZ; Healon; Hylan; Hyalgan; Non-Animal Stabilized Hyaluronic Acid (NASHA)
EINECS	Contact for details

Quality Control

Our Physiogel is manufactured under strict cGMP guidelines and undergoes rigorous quality testing to ensure compliance with relevant pharmacopeial standards such as USP, EP, and JP. Each batch is characterized for critical parameters including molecular weight distribution, purity, and biological safety. Certificates of Analysis (COA) detailing identity, assay, endotoxin levels, and microbiological purity are available upon request to support your regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent moisture uptake. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white fibrous powder or granules
Identification (IR)	Conforms
Assay (as Sodium Hyaluronate)	≥ 95.0 %
Molecular Weight	As per grade requirement (e.g., 0.5 - 3.0 x 106 Da)
Protein Content	≤ 0.3 %
Heavy Metals	≤ 20 ppm
Endotoxin	< 0.05 EU/mg (for injectable grades)
Microbial Limits	Meets Ph. Eur. 2.6.12 / USP <61> requirements
pH (1% solution)	6.0 - 8.0
Loss on Drying	≤ 10.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.