Description

Erythromycin 2'-Acetate CAS NO 992-69-8 is a key pharmaceutical intermediate derived from the macrolide antibiotic erythromycin. This compound is of significant commercial importance for the synthesis of advanced erythromycin derivatives with enhanced stability and bioavailability. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibiotic formulations.

Application

• Pharmaceutical Intermediate: Critical starting material for the synthesis of second-generation macrolide antibiotics, such as clarithromycin and other semi-synthetic derivatives.
• Antibiotic Research & Development: Used in medicinal chemistry to study structure-activity relationships (SAR) and develop new antimicrobial agents with improved pharmacokinetic profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the multi-step synthesis of complex antibiotic APIs under controlled GMP environments.
• Process Chemistry: Serves as a standard reference compound and a key reagent in optimizing large-scale fermentation and chemical modification processes.
• Veterinary Medicine: Potential use in the development of antibiotic treatments for animal health.

Basic Information

Product Name	Erythromycin 2'-Acetate
CAS No.	992-69-8
Molecular Formula	C39H67NO14
Molecular Weight	773.95 g/mol
Synonyms	Erythromycin 2'-Acetate; Erythromycin B 2'-Acetate; Erythromycin B acetate; 2'-O-Acetylerythromycin; Erythromycin acetate (ambiguous); (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2,10-dione 2-acetate
EINECS	Contact for details

Quality Control

Our Erythromycin 2'-Acetate is produced and tested to meet stringent quality standards suitable for pharmaceutical intermediate applications. We implement a rigorous QC protocol that includes identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing specifications for assay, related substances, residual solvents, and other critical parameters. Our quality system supports compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.