Description

4'-tert-Butylacetophenone CAS NO 943-27-1 is a specialized aromatic ketone derivative, serving as a crucial intermediate in advanced organic synthesis. Its value lies in its unique molecular structure, which provides a sterically hindered tert-butyl group adjacent to the acetyl functionality, enabling selective chemical transformations. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries seeking to build complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a hindered aromatic ketone moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the tert-butyl group enhances biological activity and stability.
• Fine Chemical & Fragrance Precursor: Acts as a starting material for synthesizing specialty chemicals, aroma compounds, and liquid crystal materials.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D for Friedel-Crafts acylation studies, ligand synthesis, and the development of novel organic methodologies.
• Polymer Chemistry: Can be utilized as a monomer or modifier in the synthesis of specialty polymers with tailored thermal and optical properties.

Basic Information

Item	Details
Product Name	4'-tert-Butylacetophenone
CAS No.	943-27-1
Molecular Formula	C₁₂H₁₆O
Molecular Weight	176.26 g/mol
Synonyms	1-[4-(1,1-Dimethylethyl)phenyl]ethanone; 4-tert-Butylacetophenone; p-tert-Butylacetophenone; 4-(tert-Butyl)acetophenone; 4'-tert-Butyl Acetophenone; 4-(1,1-Dimethylethyl)acetophenone; Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]-; NSC 403697
EINECS	213-395-5

Quality Control

Our 4'-tert-Butylacetophenone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request, providing full traceability and quality assurance for your regulatory and internal compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Melting Point	50 - 54 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.