Description

3'-Chloro-3-(2,4-Dimethylphenyl)-5'-Fluoropropiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system disorders. It is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries engaged in developing new therapeutic agents and proprietary chemical entities.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Organic Synthesis Research: Used in academic and industrial R&D for studying structure-activity relationships (SAR) and developing new synthetic methodologies for halogenated ketones.
• Agrochemical Precursor: Serves as a precursor in the development of advanced crop protection agents and pesticides, leveraging its halogenated aromatic system.
• Material Science Chemical: Employed in the research and development of specialty polymers and advanced organic materials requiring specific aromatic backbones.

Basic Information

Product Name	3'-Chloro-3-(2,4-Dimethylphenyl)-5'-Fluoropropiophenone
CAS No.	898794-40-6
Molecular Formula	C17H16ClFO
Molecular Weight	290.76 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(2,4-dimethylphenyl)propan-1-one; 3'-Chloro-5'-fluoro-3-(2,4-dimethylphenyl)propiophenone; 898794-40-6; Propiophenone, 3'-chloro-3-(2,4-dimethylphenyl)-5'-fluoro-; 3-(2,4-Dimethylphenyl)-1-(3-chloro-5-fluorophenyl)propan-1-one
EINECS	Contact for details

Quality Control

Our 3'-Chloro-3-(2,4-Dimethylphenyl)-5'-Fluoropropiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced analytical techniques like HPLC, GC, and NMR. We adhere to cGMP guidelines where applicable to meet the stringent requirements of pharmaceutical development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.