Description

4-Chloro-2-Fluorophenyl Cyclopentyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorophenyl moiety can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals, leveraging its aromatic and ketone functionalities.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Chloro-2-Fluorophenyl Cyclopentyl Ketone
CAS No.	898791-75-8
Molecular Formula	C₁₂H₁₂ClFO
Molecular Weight	226.67 g/mol
Synonyms	Cyclopentyl(4-chloro-2-fluorophenyl)methanone; 1-(4-Chloro-2-fluorophenyl)-1-cyclopentylmethanone; 4-Chloro-2-fluoro-1-(cyclopentanecarbonyl)benzene; 4-Chloro-2-fluorobenzoylcyclopentane; 898791-75-8; 4-Chloro-2-fluorophenyl cyclopentyl ketone; 4-Chloro-2-fluorobenzoyl cyclopentane
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenyl Cyclopentyl Ketone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 97% (HPLC). Each lot undergoes comprehensive analytical testing including HPLC for assay and impurity profiling, GC for residual solvents, and 1H/13C NMR and IR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.