Description

Cyclobutyl 3,4-Difluorophenyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorophenyl and cyclobutyl motifs can impart desirable metabolic stability and binding properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals for electronic and optical applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical manufacturers offering bespoke synthesis services to clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in fluorination chemistry and cross-coupling reactions.

Basic Information

Product Name	Cyclobutyl 3,4-Difluorophenyl Ketone
CAS No.	898791-28-1
Molecular Formula	C11H10F2O
Molecular Weight	196.19 g/mol
Synonyms	3,4-Difluorophenyl Cyclobutyl Ketone; 1-(3,4-Difluorophenyl)-2-cyclobutanone; Cyclobutyl(3,4-difluorophenyl)methanone; (3,4-Difluorophenyl)(cyclobutyl)methanone; 898791-28-1; Cyclobutyl 3,4-Difluorobenzene Ketone; 3',4'-Difluorocyclobutylphenyl ketone
EINECS	Contact for details

Quality Control

Our Cyclobutyl 3,4-Difluorophenyl Ketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.