Description

4'-Chloro-2'-Fluoro-3-(3-Methylphenyl)Propiophenone is a high-purity, fluorinated and chlorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its precise molecular architecture makes it a critical intermediate for the development of novel, complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists engaged in the synthesis of active pharmaceutical ingredients (APIs), crop protection agents, and other fine chemicals where the introduction of specific halogenated motifs is required.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity of its halogenated structure.
• Material Science Research: Used in the synthesis of specialized monomers or ligands for advanced polymers, liquid crystals, or metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Can be utilized as a scaffold or tagging agent in the design of molecular probes for studying enzyme function or protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-3-(3-Methylphenyl)Propiophenone
CAS No.	898791-20-3
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-(3-methylphenyl)propan-1-one; 3-(3-Methylphenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 4'-Chloro-2'-fluoro-3-(m-tolyl)propiophenone; 898791-20-3; Propiophenone, 4'-chloro-2'-fluoro-3-(3-methylphenyl)-
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-2'-Fluoro-3-(3-Methylphenyl)Propiophenone is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes HPLC purity ≥98% (typical), with detailed impurity profiling available. A Certificate of Analysis (COA) documenting all critical parameters is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.