Description

3'-Chloro-5'-Fluoro-3-(3-Methylphenyl)Propiophenone is a high-purity, advanced pharmaceutical intermediate characterized by its specific halogenated aromatic structure. This compound matters for its critical role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. Pharmaceutical R&D and manufacturing teams need this intermediate to develop and scale production of new drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: Primary use as a key synthon in the multi-step synthesis of novel drug candidates.
• API Development: Serves as a crucial precursor in the research and development of new Active Pharmaceutical Ingredients, especially in central nervous system (CNS) and oncology-related therapies.
• Chemical Research: Used in academic and industrial laboratories for methodological studies in organic synthesis and halogenation chemistry.
• Agrochemical Synthesis: Potential application as an intermediate in the development of advanced crop protection agents and herbicides.
• Material Science: Exploration of its use in the synthesis of specialty polymers and liquid crystals due to its rigid, substituted aromatic core.

Basic Information

Product Name	3'-Chloro-5'-Fluoro-3-(3-Methylphenyl)Propiophenone
CAS No.	898791-17-8
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(3-Chloro-5-fluorophenyl)-3-(3-methylphenyl)-1-propanone; 3'-Chloro-5'-fluoro-3-(m-tolyl)propiophenone; Propiophenone, 3'-chloro-5'-fluoro-3-(3-methylphenyl)-; 3-(3-Methylphenyl)-1-(3-chloro-5-fluorophenyl)propan-1-one; m-Tolyl 3-chloro-5-fluorobenzyl ketone derivative
EINECS	Contact for details

Quality Control

Our 3'-Chloro-5'-Fluoro-3-(3-Methylphenyl)Propiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical R&D. Production adheres to cGMP principles where applicable. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our rigorous quality testing includes advanced chromatographic methods to meet the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 15°C and 25°C. Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.