Description

4-Chloro-2-Fluorophenyl Cyclobutyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated cyclobutyl structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a versatile precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, facilitating challenging cross-coupling and asymmetric synthesis reactions.
• Material Science Research: Employed as a monomer or functionalization agent in the synthesis of advanced polymers and liquid crystals with tailored optical or electronic properties.
• Chemical Biology Probes: Acts as a building block for creating molecular probes and tags used in biochemical assay development and diagnostic research.

Basic Information

Product Name	4-Chloro-2-Fluorophenyl Cyclobutyl Ketone
CAS No.	898791-09-8
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	Cyclobutyl(4-chloro-2-fluorophenyl)methanone; 1-(4-Chloro-2-fluorophenyl)-1-cyclobutanone; 4-Chloro-2-fluoro-1-(cyclobutanecarbonyl)benzene; 4-Chloro-2-fluorobenzoylcyclobutane; 898791-09-8; 4-Chloro-2-fluorophenyl cyclobutyl ketone; (4-Chloro-2-fluorophenyl)(cyclobutyl)methanone
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluorophenyl Cyclobutyl Ketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.