Description

3-Chloro-5-Fluorophenyl Cyclobutyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated cyclobutyl structure enables precise molecular design. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated phenyl group enhances bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the development of organic electronic materials, such as semiconductors and liquid crystals, due to its conjugated ketone system.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new chemical spaces in fluoroorganic chemistry.

Basic Information

Product Name	3-Chloro-5-Fluorophenyl Cyclobutyl Ketone
CAS No.	898791-06-5
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	Cyclobutyl(3-chloro-5-fluorophenyl)methanone; 1-(3-Chloro-5-fluorophenyl)cyclobutan-1-one; 3-Chloro-5-fluorobenzoylcyclobutane; (3-Chloro-5-fluorophenyl)(cyclobutyl)ketone; Ketone, 3-chloro-5-fluorophenyl cyclobutyl; 898791-06-5; 3-Chloro-5-fluoro cyclobutyl phenyl ketone
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorophenyl Cyclobutyl Ketone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, and we support regulatory documentation for REACH and other global compliance standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.