Description

2-Chloro-4-Fluorophenyl Cyclobutyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated cyclobutyl structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the fluorine and chlorine substituents for enhanced bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of advanced organic materials, including liquid crystals and polymers with tailored optical or electronic properties.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for custom chemical synthesis services catering to the needs of biotechnology and fine chemical companies.

Basic Information

Product Name	2-Chloro-4-Fluorophenyl Cyclobutyl Ketone
CAS No.	898791-03-2
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	Cyclobutyl(2-chloro-4-fluorophenyl)methanone; 1-(2-Chloro-4-fluorophenyl)-1-cyclobutanone; 2-Chloro-4-fluorophenyl cyclobutyl ketone; 2-Chloro-4-fluoro-1-(cyclobutanecarbonyl)benzene; (2-Chloro-4-fluorophenyl)(cyclobutyl)methanone; 898791-03-2; Ketone, 2-chloro-4-fluorophenyl cyclobutyl
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluorophenyl Cyclobutyl Ketone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.