Description

4-Bromo-2-Fluorophenyl Cyclobutyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on the phenyl ring adjacent to a cyclobutyl ketone moiety, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its electron-withdrawing halogen groups.
• Material Science: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	4-Bromo-2-Fluorophenyl Cyclobutyl Ketone
CAS No.	898791-00-9
Molecular Formula	C11H10BrFO
Molecular Weight	257.10 g/mol
Synonyms	Cyclobutyl(4-bromo-2-fluorophenyl)methanone; 4-Bromo-2-fluoro-1-(cyclobutanecarbonyl)benzene; 1-(4-Bromo-2-fluorophenyl)cyclobutan-1-one; 4-Bromo-2-fluorobenzoyl cyclobutane; 898791-00-9; (4-Bromo-2-fluorophenyl)(cyclobutyl)methanone
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 4-Bromo-2-Fluorophenyl Cyclobutyl Ketone is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We adhere to strict in-house specifications designed for research and development applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.