Description

4'-Chloro-3'-Fluoro-3-(3-Methylphenyl)Propiophenone is a high-purity fluorinated and chlorinated aromatic ketone, serving as a critical advanced pharmaceutical intermediate (API intermediate). Its precise molecular architecture makes it an essential building block for synthesizing complex active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily required by R&D laboratories and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug molecules, particularly those targeting central nervous system (CNS) disorders, inflammatory conditions, or oncological pathways.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine and chlorine substituents can enhance biological activity and environmental stability.
• Material Science Research: Acts as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials due to its aromatic and halogenated structure.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical chemistry laboratories.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, carbonyl chemistry, and other transformations to introduce specific functionalized aromatic motifs.

Basic Information

Product Name	4'-Chloro-3'-Fluoro-3-(3-Methylphenyl)Propiophenone
CAS No.	898790-90-4
Molecular Formula	C16H14ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(4-Chloro-3-fluorophenyl)-3-(3-methylphenyl)-1-propanone; 3'-Methyl-4'-chloro-3-fluoropropiophenone; 3-(3-Methylphenyl)-1-(4-chloro-3-fluorophenyl)propan-1-one; 4-Chloro-3-fluoro-3'-(3-methylphenyl)propiophenone; 898790-90-4; Propiophenone, 4'-chloro-3'-fluoro-3-(3-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 4'-Chloro-3'-Fluoro-3-(3-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, confirming compliance with client specifications and current industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.