Description

4-Chloro-3-Fluorophenyl Cyclobutyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated cyclobutyl structure enables precise molecular modifications. Pharmaceutical research and fine chemical manufacturing companies need this material to synthesize complex molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs exploring kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides and fungicides, leveraging the bioactivity of the fluorinated phenyl moiety.
• Ligand and Catalyst Development: Used in research to create specialized ligands for transition metal catalysis and organocatalysts due to its sterically defined cyclobutyl group.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals or polymers with specific optical or electronic properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Chloro-3-Fluorophenyl Cyclobutyl Ketone
CAS No.	898790-85-7
Molecular Formula	C11H10ClFO
Molecular Weight	212.65 g/mol
Synonyms	Cyclobutyl(4-chloro-3-fluorophenyl)methanone; 1-(4-Chloro-3-fluorophenyl)cyclobutan-1-one; 4-Chloro-3-fluorobenzoylcyclobutane; (4-Chloro-3-fluorophenyl)(cyclobutyl)ketone; Ketone, 4-chloro-3-fluorophenyl cyclobutyl; 898790-85-7; 4-Chloro-3-fluoro cyclobutyl phenyl ketone
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorophenyl Cyclobutyl Ketone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure a typical purity of ≥97% (by HPLC) and conformity to client specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where required, ensuring traceability and consistency for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.