Description

Cyclopropyl 3,4-Difluorophenyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorophenyl and cyclopropyl motifs can impart desirable metabolic stability and binding properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in constructing advanced herbicide and pesticide molecules, leveraging the fluorine atoms for enhanced bioactivity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals, where fluorine incorporation modifies material properties.
• Custom Synthesis & Contract Manufacturing: A valuable building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic Research: Utilized in university and institutional labs for methodological studies in fluorination chemistry and cross-coupling reactions.

Basic Information

Product Name	Cyclopropyl 3,4-Difluorophenyl Ketone
CAS No.	898790-32-4
Molecular Formula	C10H8F2O
Molecular Weight	182.17 g/mol
Synonyms	3,4-Difluorophenyl Cyclopropyl Ketone; 1-Cyclopropyl-2-(3,4-difluorophenyl)ethanone; (3,4-Difluorophenyl)(cyclopropyl)methanone; Cyclopropyl(3,4-difluorophenyl)methanone; 3',4'-Difluoropropiophenone (cyclopropyl analog); CPDFK; Ketone, cyclopropyl 3,4-difluorophenyl
EINECS	Contact for details

Quality Control

Our Cyclopropyl 3,4-Difluorophenyl Ketone is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.