Description

4-Bromo-2-Fluorophenyl Cyclopropyl Ketone is a high-purity fluorinated and brominated aromatic ketone building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which allows for selective functionalization at multiple reactive sites, enabling the construction of complex heterocyclic and pharmaceutical intermediates. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry and catalyst ligand design.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new generation herbicides and fungicides, leveraging the bioactivity imparted by the halogen and ketone functional groups.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or electronic properties.
• Chemical Synthesis Building Block: Employed in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to introduce the 4-bromo-2-fluorophenyl moiety into more complex molecules.
• Ligand Synthesis: The cyclopropyl ketone group can be transformed into chiral ligands for asymmetric catalysis.
• Life Science Research: Utilized as a standard or reagent in academic and industrial R&D for probing biochemical pathways and protein interactions.

Basic Information

Product Name	4-Bromo-2-Fluorophenyl Cyclopropyl Ketone
CAS No.	898790-15-3
Molecular Formula	C10H8BrFO
Molecular Weight	243.07 g/mol
Synonyms	Cyclopropyl(4-bromo-2-fluorophenyl)methanone; 1-(4-Bromo-2-fluorophenyl)-1-cyclopropylmethanone; 4-Bromo-2-fluoro-α-cyclopropylbenzyl alcohol ketone; 2-Fluoro-4-bromophenyl cyclopropyl ketone; (4-Bromo-2-fluorophenyl)(cyclopropyl)methanone; CPK-BrF
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Fluorophenyl Cyclopropyl Ketone is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. Our products are developed to meet the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and MS, is provided with each shipment to guarantee supply reliability and technical compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.