Description

3',5'-Difluoro-3-(2-Methylphenyl)Propiophenone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its precise molecular architecture, featuring a difluorinated propiophenone core and an ortho-methylphenyl substituent, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by pharmaceutical R&D and fine chemical sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for fluorinated components in electronic display and lighting technologies.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique thermal and chemical resistance profiles.
• Academic & Contract Research: Essential for methodological studies in fluorination chemistry and cross-coupling reactions.
• Custom Synthesis & Scale-up: Supplied for process development and pilot-scale production of target molecules in a cGMP environment.

Basic Information

Product Name	3',5'-Difluoro-3-(2-Methylphenyl)Propiophenone
CAS No.	898790-14-2
Molecular Formula	C16H14F2O
Molecular Weight	260.28 g/mol
Synonyms	1-(3,5-Difluorophenyl)-3-(2-methylphenyl)propan-1-one; 3,5-Difluoro-3'-(2-methylphenyl)propiophenone; 3-(2-Methylphenyl)-1-(3,5-difluorophenyl)-1-propanone; 3',5'-Difluoro-3-(o-tolyl)propiophenone; 898790-14-2; Propiophenone, 3',5'-difluoro-3-(2-methylphenyl)-; 1-Propanone, 1-(3,5-difluorophenyl)-3-(2-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoro-3-(2-Methylphenyl)Propiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production can support development needs from research quantities to commercial scale, with quality protocols aligned with ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.