Description

4-Chloro-3-Fluorophenyl Cyclopropyl Ketone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique halogenated structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorophenyl moiety for enhanced biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals, where fluorinated aromatic systems are valuable.
• Custom Synthesis and Contract Manufacturing: A requested intermediate for bespoke chemical synthesis services catering to R&D and pilot-scale production.
• Academic and Industrial R&D: Utilized in exploratory chemistry for method development and the creation of compound libraries for high-throughput screening.

Basic Information

Product Name	4-Chloro-3-Fluorophenyl Cyclopropyl Ketone
CAS No.	898790-06-2
Molecular Formula	C10H8ClFO
Molecular Weight	198.62 g/mol
Synonyms	Cyclopropyl(4-chloro-3-fluorophenyl)methanone; 1-(4-Chloro-3-fluorophenyl)cyclopropan-1-one; 4-Chloro-3-fluorobenzoylcyclopropane; (4-Chloro-3-fluorophenyl)(cyclopropyl)ketone; 898790-06-2; 4-Chloro-3-fluoro cyclopropyl phenyl ketone; Ketone, 4-chloro-3-fluorophenyl cyclopropyl
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluorophenyl Cyclopropyl Ketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.