Description

4'-Chloro-2'-Fluoro-3-(2-Methylphenyl)Propiophenone is a specialized fluorinated and chlorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, high-value molecules, particularly within the pharmaceutical sector. It is primarily needed by research chemists and process development scientists in the fine chemical and pharmaceutical industries for creating novel active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the fluorine and chlorine substituents can enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or building block for synthesizing specialized polymers and liquid crystals with unique optical or electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, such as Suzuki or Heck reactions, to construct complex biaryl systems due to its halogenated aromatic structure.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for methodological studies in fluorination chemistry and asymmetric synthesis.

Basic Information

Product Name	4'-Chloro-2'-Fluoro-3-(2-Methylphenyl)Propiophenone
CAS No.	898789-91-8
Molecular Formula	C₁₆H₁₄ClFO
Molecular Weight	276.73 g/mol
Synonyms	1-(4-Chloro-2-fluorophenyl)-3-(o-tolyl)propan-1-one; 3-(2-Methylphenyl)-1-(4-chloro-2-fluorophenyl)propan-1-one; 4'-Chloro-2'-fluoro-3-(o-tolyl)propiophenone; 898789-91-8; Propiophenone, 4'-chloro-2'-fluoro-3-(2-methylphenyl)-; 1-Propanone, 1-(4-chloro-2-fluorophenyl)-3-(2-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 4'-Chloro-2'-Fluoro-3-(2-Methylphenyl)Propiophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.