Description

3-(2-Methylphenyl)-3'-Trifluoromethylpropiophenone is a specialized organic intermediate featuring a propiophenone core substituted with a 2-methylphenyl group and a trifluoromethylphenyl group. This molecular architecture makes it a valuable building block for the synthesis of more complex fluorinated compounds, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in fine chemical synthesis. The compound's defined structure and purity are critical for ensuring reproducibility in downstream reactions.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those incorporating the trifluoromethyl group for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms can improve lipophilicity and biological activity.
• Liquid Crystal & OLED Material Synthesis: Acts as a building block for fluorinated organic molecules used in electronic displays and optoelectronic devices.
• Advanced Polymer Chemistry: Employed to introduce fluorinated aromatic units into polymer backbones, modifying properties like chemical resistance, thermal stability, and dielectric constant.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule construction and scale-up projects.

Basic Information

Product Name	3-(2-Methylphenyl)-3'-Trifluoromethylpropiophenone
CAS No.	898789-76-9
Molecular Formula	C17H15F3O
Molecular Weight	292.30 g/mol
Synonyms	1-[3-(Trifluoromethyl)phenyl]-3-(2-methylphenyl)propan-1-one; 3'-Trifluoromethyl-3-(o-tolyl)propiophenone; 3-(2-Methylphenyl)-1-[3-(trifluoromethyl)phenyl]-1-propanone; 3-(2-Methylphenyl)-3'-(trifluoromethyl)propiophenone; Propiophenone, 3-(2-methylphenyl)-3'-(trifluoromethyl)-; α-Ethyl-3'-(trifluoromethyl)-2-methylbenzhydrol ketone (related precursor)
EINECS	Contact for details

Quality Control

Our 3-(2-Methylphenyl)-3'-Trifluoromethylpropiophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to confirm identity and high purity levels, typically ≥97% (by HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all relevant specifications. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.