Description

3-(2-Methylphenyl)-2'-Trifluoromethylpropiophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the combination of a propiophenone backbone with methyl and trifluoromethyl substituents, offering unique electronic and steric properties for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, or insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Used in the research of advanced organic materials, such as liquid crystals or organic semiconductors, where its specific aromatic structure can influence material properties.
• Chemical Synthesis: Functions as a versatile electrophile or coupling partner in various cross-coupling reactions (e.g., Suzuki, Heck) to create more complex, diaryl-substituted structures.
• Catalyst Ligand Development: The ketone and aromatic groups can be modified to create novel chiral or non-chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-(2-Methylphenyl)-2'-Trifluoromethylpropiophenone
CAS No.	898789-73-6
Molecular Formula	C17H15F3O
Molecular Weight	292.30 g/mol
Synonyms	1-[3-(2-Methylphenyl)-1-oxopropyl]-2-(trifluoromethyl)benzene; 2'-Trifluoromethyl-3-o-tolylpropiophenone; 3-(2-Methylphenyl)-1-[2-(trifluoromethyl)phenyl]propan-1-one; 3-o-Tolyl-2'-(trifluoromethyl)propiophenone; Propiophenone, 3-(2-methylphenyl)-2'-(trifluoromethyl)-; α-Ethyl-2-methylbenzenepropanal, 2'-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-(2-Methylphenyl)-2'-Trifluoromethylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO standards ensures reliable material for your most demanding research and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.