Description

3',4'-Difluoro-3-Phenylpropiophenone is a high-value fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its core value lies in its unique molecular structure, which serves as a critical intermediate for constructing complex pharmacologically active molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where fluorination enhances efficacy and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals that require fluorinated aromatic components for improved thermal and chemical stability.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a building block for electron-transport or host materials in OLED device fabrication.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in cross-coupling reactions and fluorination chemistry.
• Custom Synthesis: A starting material for the contract manufacturing of bespoke fine chemicals and complex organic molecules for various industrial applications.

Basic Information

Product Name	3',4'-Difluoro-3-Phenylpropiophenone
CAS No.	898788-90-4
Molecular Formula	C15H12F2O
Molecular Weight	246.25 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3-phenylpropan-1-one; 3-Phenyl-1-(3,4-difluorophenyl)propan-1-one; 3',4'-Difluoro-3-phenylpropiophenone; 3,4-Difluoro-3-phenylpropiophenone; 898788-90-4; 3-Phenyl-1-(3,4-difluorophenyl)-1-propanone; Propiophenone, 3',4'-difluoro-3-phenyl-
EINECS	Contact for details

Quality Control

Our 3',4'-Difluoro-3-Phenylpropiophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.