Description

3-(4-Chlorophenyl)-3',5'-Difluoropropiophenone is a high-purity organic intermediate featuring a distinct difluorinated aromatic ketone structure. This compound is valued for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides and fungicides, leveraging the bioactivity of the difluorophenyl moiety.
• Ligand and Catalyst Development: Used in organic chemistry research for the preparation of specialized ligands and catalysts in cross-coupling reactions.
• Material Science Research: Employed as a monomer or additive in the development of specialty polymers with unique optical or electronic properties.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in manufacturing processes.

Basic Information

Product Name	3-(4-Chlorophenyl)-3',5'-Difluoropropiophenone
CAS No.	898788-49-3
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-(4-Chlorophenyl)-3-(3,5-difluorophenyl)-1-propanone; 3',5'-Difluoro-3-(4-chlorophenyl)propiophenone; 3-(4-Chlorophenyl)-1-(3,5-difluorophenyl)propan-1-one; Propiophenone, 3-(4-chlorophenyl)-3',5'-difluoro-; 898788-49-3; 3-(p-Chlorophenyl)-3',5'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Chlorophenyl)-3',5'-Difluoropropiophenone is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, GC, NMR, and mass spectrometry, to ensure compliance with industry standards and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.