Description

3-(4-Chlorophenyl)-3',4'-Difluoropropiophenone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. This compound is valued for its precise molecular structure, which serves as a critical building block in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific halogenated and fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Research: Used in the development of next-generation herbicides and fungicides, where the difluorophenyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: An effective substrate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Organic Synthesis Reference Standard: Used as a pure standard for analytical method development and validation in QC laboratories.
• Chemical Research & Development: Employed in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	3-(4-Chlorophenyl)-3',4'-Difluoropropiophenone
CAS No.	898788-47-1
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-(3,4-Difluorophenyl)-3-(4-chlorophenyl)propan-1-one; 3',4'-Difluoro-3-(4-chlorophenyl)propiophenone; 3-(4-Chlorophenyl)-1-(3,4-difluorophenyl)propan-1-one; 4-Chloro-β-(3,4-difluorobenzoyl)ethylbenzene; Propiophenone, 3-(4-chlorophenyl)-3',4'-difluoro-; 898788-47-1; 3-(p-Chlorophenyl)-3',4'-difluoropropiophenone
EINECS	Contact for details

Quality Control

Our 3-(4-Chlorophenyl)-3',4'-Difluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.